The New Standard For Behavioral And Cognitive Phenotyping In The Home Cage
- In depth screening of individual experimental animals in a social context
- Up to 16 animals per cage, efficient testing, high throughput
- Maximal standardization and reproducibility
- Minimal human intervention, high validity
- Fully automated task performance
- Broad variety of accessible data
- Flexible design of paradigms
The IntelliCage allows you to assess the home cage behavior and cognitive performance of up to 16 individual mice or rats separately while they are living in a social environment. This unique experimental setup fosters natural social behavior in a biologically relevant, enriched but highly standardized home cage context. In this way, the IntelliCage minimizes the need for handling and human intervention, thereby increasing task validity, data reproducibility and ensuring a high level of animal welfare.
RFID transponder tagged animals are individually recognized in the fully automated conditioning corners that evaluate spontaneous behavior, operant/associative learning and memory. The four corners are equipped with sensors (continuous 24h-recording of behavioral events) and actors (allowing the system to feedback on animals’ behavior in a pre-defined way). Together with the software package using a programmable user interface, this unique sensor/actor principle grants direct behavioral shaping of group-housed animals in an all-in-one system according to diverse research interests. The visually designed paradigms run fully automated, allowing for efficient continuous testing and monitoring of large experimental animal cohorts.
To date, IntelliCage data have been published in more than 100 peer-reviewed articles, among them publications in highly prestigious journals like PNAS, Molecular Psychiatry or Nature Communications. The IntelliCage has been shown to allow a transfer of validated behavioral paradigms into an automated setup, serving as a complement to usual behavioral testing procedures.
Please discuss your specific research needs with our scientific personnel!
Masuda A, Kobayashi Y, Kogo N, Saito T, Saido TC, Itohara S.
Cognitive deficits in single App knock-in mouse models.
Neurobiol Learn Mem 2016; Nov;135:73-82. Epub 2016 Jul 1.
Voikar V, Krackow S, Lipp HP, Rau A, Colacicco G, Wolfer DP.
Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage.
S0166-4328(17)30962-2. [Epub ahead of print] Behav Brain Res. 2017 pii:
Dere E, Ronnenberg A, Tampe B, Arinrad S, Schmidt M, Zeisberg E, Ehrenreich H.
Cognitive, emotional and social phenotyping of mice in an observer-independent setting.
Neurobiol Learn Mem 2018 Feb 20. pii: S1074-7427(18)30044-3. doi: 10.1016/j.nlm.2018.02.023. [Epub ahead of print]