Mechanosensitive Ion Channels
Patchliner
The Patchliner is versatile yet robust, ideal for basic research of ion channel biophysics and mechanisms of action, sophisticated assays such as heat activation, right through to routine assays such as safety screening of hERG or other cardiac ion channels in accordance with the CiPA initiative. The Patchliner is a medium throughput automated patch clamp system which comes as a 4 or 8 channel version. Experimental protocols are programmed using the PatchControlHT software which controls the Tecan robot for addition of solutions, cells and compounds, and controls the PatchMaster software for data acquisition. NPC-16 chips, the consumable for the Patchliner, can be loaded on the chip wagon and the instrument can run unattended for 48 recordings. The Patchliner is supplied as a complete system including Tecan pipetting robot, HEKA EPC10 amplifiers, NPC-16 chips, Reagent starter kit and all the required software. Add-ons for Temperature control, Cooled CellHotel and dynamic clamp (Dynamite8) are also available to expand the experimental possibilities. Our dedicated team of electrophysiologists and engineers are committed to continuous in-house assay development, software and hardware advancements, ensuring fast and custom-tailored solutions for your assay demands.
SyncroPatch 384
The SyncroPatch 384 is an automated patch clamp instrument with 384 recording channels incorporated into a state-of-art liquid handling robot. It can be used for screening large compound libraries but also for smaller screens and assay development using the 32-well mode of operation. This allows the instrument to be literally turned into a lower throughput instrument, using a fraction of the chip and pipetting head in multiples of 32 wells. The rest of the chip can be used over several days which takes further advantage of the economical price of the NPC-384 chip. The SyncroPatch 384 also includes a sophisticated temperature control which can cool as well as heat, this can be used to maintain a constant temperature or to activate cold-activated ion channels. The SyncroPatch 384 can be used in all stages of drug discovery, from hit discovery through lead optimization to safety pharmacology, and can also be used for complex biophysical analysis of ion channels in academic research. The SyncroPatch 384 is supplied as a complete system including the Biomek i5 pipetting robot, Tecella amplifier with 384 channels, NPC-384 chips, Reagent starter kit and all the required software. Temperature control, Cooled CellHotel and current clamp are all provided as standard.
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